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Cross Reaction Info

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Instant CLIA Waived devices (Point of Care Devices) can trigger false (positive or negative) results. All manufacturers encourage or mandate any positive test must be sent to Mass Spec for further interpretation.  Medical Distribution Group, Inc. offers confirmation services. Please call 727-744-2967 for more information.

If the device has triggered a disputed positive result please use this page as a list of possible cross reactions.  Please note this list is not 100% conclusive and may not include all known cross reactive drugs.  Always reference the CLIA insert included with every box purchased from Medical Distribution Group, Inc.  

Amphetamines (AMP)

  • Adderall
  • Adderall XR
  • Amantadine
  • Benzphetamine
  • Bupropion
  • Chlorpromazine
  • /-Deprenylc
  • Desipramine
  • Dextroamphetamine Sulfate
  • Dexedrine
  • Ephedrine
  • Fenproporexb
  • Isometheptene
  • Isoxsuprine
  • Labetalol
  • MDMA
  • Methamphetamine (Vick's Inhaler)
  • Methylenedioxyamphetamine (MDA)
  • Methylphenidate
  • Phentermine
  • Phenylephrine
  • Phenylpropanolamine
  • Promethazine
  • Pseudoephedrine
  • Ranitidine
  • Ritodrine
  • Selegiline
  • Thioridazine
  • Trazodone
  • trimethobenzamide
  • Trimipramine
  • Vyvanse (c)
  • Adderall, Adderall XR, Dexedrine Dextroamphetamine)

Common Over the Counter Drugs that trigger Positive results for AMP: Afrinol, Vicks Vapor Inhaler, Sudafed, Tylenol Cold, Pseudoephedrine

Slang for AMP- Eve, Love Drug, Speed, Uppers

Benzodiazepines (BZO/ BZD)

  • Oxaprozin (Daypro) NSAIDs
  • Bromopheniramine (Lexotan)
  • Sertraline
  • Xanex (Alprozolam)
  • Lexotan (Bromazepam)
  • Librium (Clordiazepoxide)
  • Frisium (Clobazam)
  • Clonopin, Klonopin, Rivotril(Clonazepam)
  • Tranxene (Clobazam)
  • Librium (Clorazepate)
  • Briantum (Delorazepam)
  • Diazemuls, Stesolid, Valclair, Valium (Diazepam)
  • ProSom (Estazolam)
  • Rohypnol (Estazolam)
  • Rohypnol, Prosom (Fluntirazepam), 
  • Alapryl, Paxipan, Pacinone (Halazepam)
  • Lofepramide, Ativan (Lorazepam)
  • Noctamide (Lormetazepam)
  • Anxitol, Lerisum, Medacepan, Nobritol, Nobrium (Medazepam)
  • Mogadon, Somnite (Nitrazepam)
  • Serax, Ox-pam (Oxazepam)
  • Centrax, Demtrin (Prazepam)
  • Zoloft (Sertraline)
  • Restoril (Temazepam)
  • Halcion (Triazolam)

Barbiturates (BAR)

  • Allobarbital
  • Alphenol
  • Amytal, Tuinal
  • Aprobarbital (Amytal, Tuinal)
  • Barbital
  • Butisol, Soneryl (Butabarbital)
  • Fioricet, Fiorinal (Butalbital)
  • Ibuprofen
  • Nembutal (Pentobarbitone)
  • Galenphol, Strong BP, Pavacol-D
  • Thebacon (Phenobarbitone)
  • Seconal (Secobarbital)
  • Phenytoin (Dilantin, Epanutin, Epitard) - Cross Reaction

Cannabinoids (THC)

  • Dronabinol
  • Efavirenz
  • Hemp-containing Foods
  • NSAIDs
  • Proton Pump Inhibitors
  • Tolmetin
  • Sustiva (Efavirenz)

Cocaine

  • Coca leaf Tea
  • Topical Anesthetics containing cocaine
  • Heavy exposure to cocaine smoke.  
  • Efavirenz (Sustiva)

Methadone (MTD)

  • Verapamil Metabolites
  • Dolophine
  • Methadose
  • Physetone (Methadone Hydrochloride)

Methamphetamine (MAMP/ M-AMP)

  • Desoxyn
  • Methedrine
  • Methamprex (d-Methamphetamine HCL)
  • Vick's Inhaler (I-Methampetamine HCL)
  • Combination: Afrinol, Sudafed & Tylenol Cold (Pseudoephedrine)
  • Pylorid
  • Zantac (Ranitidine)
  • Methylenedioxymethamphetamine (MDMA)

Opiods/ Opiates/ Heroin (OPI, MOR/MOP)

  • Dextromethorphan
  • Heroin8
  • Diphenhydraminee
  • Dihydrocofeine (Paramol, Remedeine, Remedeine Forte)
  • Heroin
  • Codeine
  • Hydromorphone
  • Hydrocodone
  • Morphine
  • Poppy Seeds (In high dosage)
  • Quinine
  • Quinolones
  • Rifampin
  • DHC Continus, Paramol, Remedeine, (Digydrcodeine)
  • Tylenol 3, Tylenol with codeine
  • Paracetamol with Codeine
  • Codafen Continus
  • Codeine Linctus
  • Strong BP (Pholcodine)
  • Pavacol-D (Pholcodine)
  • Galcodine
  • Kapake
  • Migraleve
  • Novocain (Procaine)
  • Solpadol
  • Tylex (Codeine Phosphate)
  • Ethylmorphine
  • Lorcet
  • Lortabe 
  • Vicodin (Hydrocodone)
  • Diocalm, Emtersam. Opazimes (Koalin and Morphine Mixture)
  • Dilaudid
  • Locoid C
  • Entersan
  • Opazimes (Koalin and Morphone Mixture)
  • Astramorph (Morphine)
  • Cyclimorph (Morphine)
  • Duramorph (Morphine)
  • Morcap (Morphine)
  • Morphone Sulfate (Morphine)
  • MS Contin (Morphine)
  • Oramorph (Morphine)
  • Roxanol (Morphine)
  • Severedol(Morphine)

Oxycodone (OXY)

  • Oxycontin
  • Percodan
  • Roxicet (Oxycodone)
  • Dilaudid, Hydrostat (Hydrocodone)
  • Lorcet, Loratab, Vicodin (Hydrocodone)

Phencyclidine (PCP)

  • Dextromethorphan
  • Diphenhydraminee
  • Doxylamine
  • Ibuprofen
  • Imipramine
  • Ketamine
  • Meperidine
  • Mesoridazine
  • Thioridazine
  • Tramodol
  • Venlafaxine
  • O-desmethylvenlafaxine
  • Lamitcal (Lamotrigine)
  • Venlafaxine (Effexor, Effexor XL)

Tricyclic Antidepressants (TCA)

  • Carbamazepinef
  • Cyclobenzaprine
  • Cyprobenzaprine
  • Diphenhydramine
  • Flexeril
  • Periactin
  • Hydroxyzine
  • Quetiapine
  • Elavil (Amitripthyline)
  • Lentizol
  • Tryptizol
  • Triptafen
  • Sinequan
  • Xepin (Doxepin)
  • Gamanil
  • Lomont (Lofepramine)
  • Promithazine (Allerfen, Anergan, Antiaus, Aprobit, Avomine, Baymethzine, Diprozin, Fenergan, Methazine, Phenergen)
  • Dothiepin (Prothiaden)

    Tricyclic Antidepressants (TCA) False Positive Information

    Although assays for drugs of abuse do not routinely test for TCAs, rapid screening for TCA in the urine is often valuable in emergency situations, such as intentional over dose or toxicity. Results of urine screening for TCA have an important role in determining early management of patients; however, many commonly prescribed and over-the counter medications can lead to false-positive results from TCA assays. The 3-ring nucleus of TCAs is the characteristic structure of this class of antidepressants. Several structurally related medications (ie, 3-ringed structures) have been shown to cross-react with TCAs in either serum or urine immunoassays. Antihistamine agents (eg, cyproheptadine, carbamazepine, cyclobenzaprine, and quetiapine) have often been reported to interfere with the serum immunoassay for TCAs because of their 3-ringed structures. Although structurally dissimilar to TCAs, the antihistamines diphenhydramine, hydroxyzine, and cetirizine (hydroxyzine’s metabolite) have also been shown to interfere with TCA immunoassay in overdose situations. Unfortunately, these case reports did not test for interference in the urine immunoassay, except for quetiapine and cyclobenzaprine.

 

 

 

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